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Hawan jini a lokacin daukar ciki na iya haifar da eclampsia da haihuwa kafin haihuwa kuma shine babban sanadin kamuwa da cutar uwa da jarirai da mutuwa. A matsayin ma'aunin kiwon lafiyar jama'a mai mahimmanci, Hukumar Lafiya ta Duniya (WHO) ta ba da shawarar cewa mata masu juna biyu waɗanda ba su da isasshen abinci mai gina jiki na calcium su ƙara 1000 zuwa 1500 MG na calcium kowace rana. Koyaya, saboda ƙayyadaddun ƙayyadaddun kariyar calcium, aiwatar da wannan shawarar bai gamsar ba.

Gwaje-gwajen da aka yi a Indiya da Tanzaniya wanda Farfesa Wafie Fawzi na Makarantar Kiwon Lafiyar Jama'a ta Harvard a Amurka ya yi ya gano cewa ƙarar ƙwayar calcium a lokacin daukar ciki ba ta da muni fiye da yawan ƙwayar calcium don rage haɗarin pre-eclampsia. Dangane da rage haɗarin haihuwa kafin haihuwa, gwajin Indiya da Tanzaniya sun sami sakamako mara daidaituwa.

Gwajin biyun sun haɗa da mahalarta 11,000 masu shekaru ≥18 shekaru, shekarun haihuwa

Don preeclampsia, yawan abin da ya faru na 500 MG tare da ƙungiyar 1500 a cikin gwajin Indiya shine 3.0% da 3.6%, bi da bi (RR, 0.84; 95% CI, 0.68 ~ 1.03); A cikin gwajin Tanzaniya, abin da ya faru shine 3.0% da 2.7%, bi da bi (RR, 1.10; 95% CI, 0.88 ~ 1.36). Duk gwaje-gwajen biyu sun nuna cewa haɗarin preeclampsia bai fi muni ba a cikin ƙungiyar 500 MG fiye da ƙungiyar 1500 MG.

Don haihuwar haihuwa, a cikin gwajin Indiya, abubuwan da suka faru na 500 MG tare da 1500 MG sun kasance 11.4% da 12.8%, bi da bi (RR, 0.89; 95% CI, 0.80 ~ 0.98), an kafa ƙarancin ƙarancin ƙima a cikin ƙimar kofa na 1.54; A cikin gwajin Tanzaniya, yawan haihuwa na haihuwa ya kasance 10.4% da 9.7%, bi da bi (RR, 1.07; 95% CI, 0.95 ~ 1.21), ya zarce ƙimar ƙarancin ƙarancin 1.16, kuma ba a tabbatar da rashin ƙarancin ba.

A cikin duka biyu na biyu da aminci na ƙarshe, babu wata shaida cewa ƙungiyar 1500 MG ta fi ƙungiyar 500 MG. Binciken meta-bincike na sakamakon gwaje-gwajen guda biyu bai sami bambance-bambance tsakanin ƙungiyoyin 500 MG da 1500 MG a cikin preeclampsia, haɗarin haihuwa da wuri, da sakandare da sakamakon aminci.

Wannan binciken ya mayar da hankali kan muhimmin batun kiwon lafiyar jama'a na kariyar calcium a cikin mata masu juna biyu don rigakafin preeclampsia, kuma an gudanar da wani babban gwaji na sarrafawa a cikin kasashe biyu lokaci guda don amsa tambaya mai mahimmanci amma har yanzu ba a san kimiyya ba game da mafi kyawun maganin ƙwayar calcium. Binciken yana da tsattsauran ƙira, babban girman samfurin, placebo mai makafi sau biyu, hasashe mara ƙarancin ƙasƙanci, da mahimman sakamako na asibiti guda biyu na preeclampsia da haihuwa a matsayin maki biyu na ƙarshe, wanda ya biyo baya har zuwa kwanaki 42 bayan haihuwa. A lokaci guda, ingancin kisa ya kasance mai girma, yawan asarar da aka samu ya ragu sosai (99.5% bin sakamakon ciki, Indiya, 97.7% Tanzaniya), kuma yarda ya kasance mai girma: matsakaicin matsakaici na yarda ya kasance 97.7% (Indiya, 93.2-99.2 interquartile interval, 8.2.7-9%). tsaka-tsakin tsaka-tsakin lokaci).

Calcium wani sinadari ne da ake bukata don girma da ci gaban tayin, kuma buqatar calcium a cikin mata masu juna biyu yana ƙaruwa idan aka kwatanta da yawan jama'a, musamman ma a ƙarshen ciki lokacin da tayin yayi girma da sauri kuma ya haɓaka ma'adinan kashi, ana buƙatar ƙara yawan calcium. Kariyar sinadarin Calcium kuma na iya rage sakin hormone parathyroid da maida hankali na calcium a cikin mata masu juna biyu, da rage raguwar tasoshin jini da santsin tsokar mahaifa. Gwaje-gwajen da aka sarrafa na placebo sun nuna cewa yawan adadin calcium a lokacin daukar ciki (> 1000 MG) ya rage haɗarin preeclampsia fiye da 50% da haɗarin haihuwa da kashi 24%, kuma raguwa ya bayyana ya fi girma a cikin mutanen da ke da ƙananan ƙwayar calcium. Saboda haka, a cikin "Shawarwari da aka Shawarar don Ƙarfin Calcium a lokacin Ciki don Hana Preeclampsia da Matsalolinsa" da Hukumar Lafiya ta Duniya (WHO) ta bayar a watan Nuwamba 2018, an ba da shawarar cewa mutanen da ke da ƙananan ƙwayar calcium su kara yawan calcium tare da 1500 zuwa 2000 MG kowace rana, rarraba zuwa kashi uku na baka, da kuma hana preclamps tsakanin sa'o'i da yawa tsakanin shan baƙin ƙarfe. Yarjejeniyar ƙwararrun ƙwararrun kasar Sin game da ƙara sinadarin Calcium ga mata masu juna biyu, wanda aka fitar a watan Mayun 2021, ya ba da shawarar cewa mata masu juna biyu masu ƙarancin ƙwayar calcium su ƙara MG 1000 ~ 1500 kowace rana har zuwa lokacin haihuwa.

A halin yanzu, wasu ƙasashe da yankuna kaɗan ne kawai suka aiwatar da kariyar ƙwayar calcium na yau da kullun a lokacin daukar ciki, dalilan sun haɗa da babban adadin nau'in nau'in sinadari na calcium, da wuya a haɗiye, tsarin gudanarwa mai rikitarwa (sau uku a rana, kuma ana buƙatar rabuwa da ƙarfe), kuma an rage yarda da magani; A wasu yankuna, saboda ƙayyadaddun albarkatu da tsada mai tsada, calcium ba shi da sauƙi a samu, don haka yuwuwar ƙara yawan ƙwayar calcium ya shafi. A cikin gwaje-gwajen gwaje-gwajen binciken ƙananan ƙwayar calcium a lokacin daukar ciki (mafi yawan 500 MG kowace rana), ko da yake idan aka kwatanta da placebo, an rage haɗarin preeclampsia a cikin ƙungiyar haɓakar calcium (RR, 0.38; 95% CI, 0.28 ~ 0.52), amma ya zama dole a san da wanzuwar bincike mai zurfi mai haɗari [3]. A cikin ƙaramin gwajin asibiti ɗaya ne kawai aka kwatanta karancin ƙimar kuɗi, haɗarin preeclamsia ya bayyana da ƙungiyar ƙasa (RR, 0.42; 95% ci, 0.18 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96 ~ 0.96); Babu wani bambanci a cikin haɗarin haihuwar haihuwa (RR, 0.31; 95% CI, 0.09 ~ 1.08)